Hydrochloric Acid → 4-(7-Fluoro-2,3-dihydrobenzofuran-2-yl)piperidine hydrochloride

Participants

Reaction Steps

To a solution of tert-butyl 4-(7-fluoro-2,3-dihydrobenzofuran-2-yl)piperidine-1-carboxylate (2.36 g, 7.34 mmol) in MeOH (43.2 mL) was added HCl in dioxane (4 M, 26.8 mL, 107 mmol). Upon completion of addition, the mixture was stirred at room temperature for 5 h. After this time, the solvent was removed under reduced pressure to afford Compound 3D as a yellow oil (1.826 g, 97% yield), which was used in the next reaction without further purification. LC/MS (m/z)=222 (M+H)+.

Provenance & Evidence