1-Propanesulfonyl chloride → 2-[4-[7-fluoro-5-(1-propylsulfonyl-3,6-dihydro-2H-pyridin-4-yl)-2,3-dihydro-1-benzofuran-2-yl]piperidin-1-yl]-5-propylpyrimidine

Participants

Reaction Steps

Example 5 was prepared from Compound 3H and propane-1-sulfonyl chloride in a similar manner to the procedure described in Example 1. 1H NMR (500 MHz, CDCl3) δ ppm 8.15 (s, 2 H), 6.95 (s, 1 H), 6.92 (d, J=12.1 Hz, 1 H), 5.94 (ddd, J=3.4, 1.9, 1.8 Hz, 1 H), 4.76-4.87 (m, 2 H), 4.63-4.73 (m, 1 H), 3.97 (q, J=2.8 Hz, 2 H), 3.53 (t, J=5.6 Hz, 2 H), 3.24 (dd, J=15.7, 9.1 Hz, 1 H), 3.04 (dd, J=15.7, 8.3 Hz, 1 H), 2.91-2.98 (m, 2 H), 2.78-2.89 (m, J=12.9, 12.9, 6.1, 2.8 Hz, 2 H), 2.52-2.59 (m, 2 H), 2.39 (t, J=7.4 Hz, 2 H), 2.05 (d, J=13.2 Hz, 1 H), 1.97 (dddd, J=11.4, 7.9, 7.7, 3.6 Hz, 1 H), 1.82-1.91 (m, 2 H), 1.75 (d, J=12.9 Hz, 1 H), 1.57 (sxt, J=7.4 Hz, 2 H), 1.39 (qd, J=12.4, 4.3 Hz, 2 H), 1.07 (t, J=7.4 Hz, 3 H), 0.93 (t, J=7.4 Hz, 3 H).

Provenance & Evidence