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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1025504Generated: October 30, 2026

Trifluoroacetic acid → 2-(4-(5-(Piperazin-1-yl)-2,3-dihydrobenzofuran-2-yl)piperidin-1-yl)-5-propylpyrimidine

https://huagongshe.com/reaction/1025504

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant4-(7-Fluoro-5-(1,2,3,6-tetrahydropyridin-4-yl)-2,3-dihydrobenzofuran-2-yl)-1-(5-propylpyrimidin-2-yl)piperidin-4-olHCID 67465776—
Reactanttert-Butyl 4-(2-(1-(5-propylpyrimidin-2-yl)piperidin-4-yl)-2,3-dihydrobenzofuran-5-yl)piperazine-1-carboxylateHCID 68211901—
Product2-(4-(5-(Piperazin-1-yl)-2,3-dihydrobenzofuran-2-yl)piperidin-1-yl)-5-propylpyrimidineHCID 67465750—

Reaction Steps

Compound 9D was prepared from Compound 9C and TFA by in a similar manner to the procedure described for Compound 1J in Example 1. LC/MS (m/z)=408 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08729084B2
Source datasetuspto-grants-2014_05
ORD IDord-2f30f36b78614252a7b0b491688705c5
Source noteuspto-grants-2014_05