Potassium Carbonate → HCID 68211507, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of tert-butyl 4-(1-(2-bromophenyl)-2-hydroxypropan-2-yl)piperidine-1-carboxylate (1.14 g, 2.86 mmol), BINAP (0.266 g, 0.427 mmol), Pd(OAc)2 (93 mg, 0.412 mmol), and K2CO3 (1.188 g, 8.59 mmol) in toluene (14.3 mL) was degassed for 10 min. After this time, the reaction mixture was heated in 110° C. oil bath overnight. At the conclusion of this period, the resulting solid was collected by filtration and rinsed with CH2Cl2. The filtrate was concentrated to afford the crude product, which was purified by column chromatography (silica gel, hexanes/EtOAc gradient 0 to 25% EtOAc) to afford Compound 11B as a colorless oil (0.959 g, 97% yield). LC/MS (m/z)=657 (2M+Na)+.

Provenance & Evidence