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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1025510Generated: October 31, 2026

Trifluoroacetic acid → 4-(5-Bromo-2-methyl-2,3-dihydrobenzofuran-2-yl)piperidine

https://huagongshe.com/reaction/1025510

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant4-(7-Fluoro-5-(1,2,3,6-tetrahydropyridin-4-yl)-2,3-dihydrobenzofuran-2-yl)-1-(5-propylpyrimidin-2-yl)piperidin-4-olHCID 67465776—
Reactanttert-Butyl 4-(5-bromo-2-methyl-2,3-dihydrobenzofuran-2-yl)piperidine-1-carboxylateHCID 68211517—
Product4-(5-Bromo-2-methyl-2,3-dihydrobenzofuran-2-yl)piperidineHCID 67465757—

Reaction Steps

Compound 11D was prepared from Compound 11C and TFA in a similar manner to the procedure described for Compound 1J in Example 1. LC/MS (m/z)=296 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08729084B2
Source datasetuspto-grants-2014_05
ORD IDord-c0918c4f6fe349bbb53ecd9adc5be44e
Source noteuspto-grants-2014_05