Dichloromethane → HCID 71715621, compound

Participants

Reaction Steps

To a mixture of 2-(4,4-dimethyl-2,5-dioxoimidazolodin-1-yl)propanoic acid CAS#876709-28-3 (130 mg, 0.65 mmol), CH2Cl2 (3 mL), Et3N (645 mg, 6.5 mmol), 4-Bromoaniline (60 mg, 0.65 mmol) was added PPAA (50% solution in DMF, 0.6 mL, 1.09 mmol). The mixture was stirred for 18 h at RT. The reaction was diluted with EtOAc washed with aq. NaHCO3 (1N solution), dried with MgSO4 and solvent removed. The crude mixture was purified by silicagel chromatography. The title compound was isolated as a white solid.

Provenance & Evidence