反应详情

2,3,4,6-Tetra-O-benzyl-D-galactitol (7.6 g) was stirred at 0° C. in pyridine (20 ml) and a solution of mesyl chloride (2.5 ml) in pyridine (20 ml) was added. The solution was stored at 4° C. overnight. TLC analysis showed completion of the reaction. The reaction mixture was partitioned between ethyl acetate and water/ice. The organic fractions were washed with 5% hydrochloric acid then saturated aqueous sodium bicarbonate solution, dried (Na2SO4) and concentrated to give a colourless oil which was used directly in the next stage.

1. customcompletion of the reaction
2. customThe reaction mixture was partitioned between ethyl acetate and water/ice
3. washThe organic fractions were washed with 5% hydrochloric acid
4. dry with materialsaturated aqueous sodium bicarbonate solution, dried (Na2SO4)
5. concentrationconcentrated
6. customto give a colourless oil which