HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-Bromo-1,3-thiazole-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methyl 2-bromothiazole-4-carboxylate | HCID 2763213 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Bromo-1,3-thiazole-4-carboxamide | HCID 45789632 | 100% |
Reaction Steps
2-Bromothiazole-4-carboxylic acid methyl ester (50 mg) was dissolved in a solution of saturated ammonia in methanol (4 ml). The reaction solution was stirred overnight at room temperature. The solvent was removed under reduced pressure to give 2-bromothiazole-4-carboxylic acid amide (46 mg, yield 100%) as a yellow solid. 1H NMR (300 MHz, CDCl3): δ 8.11 (s, 1H). LC-MS calcd for C4H3BrN2OS (m/e) 205.91, obsd 207 and 209 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729078B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-52f2b7cf8f05479d8a682b9f8f1a50e7 |
| Source note | uspto-grants-2014_05 |