2-(6-tert-butyl-1-oxophthalazin-2(1H)-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acetate → HCID 71008515, compound

Participants

Reaction Steps

This compound was prepared with the same method as described in Example 1 by using 4-bromo-1-methyl-1H-imidazole-2-carboxylic acid amide (intermediate-1) and acetic acid 2-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl ester (intermediate 4). The desired compound was prepared in two steps (33% yield). 1H NMR (300 MHz, CDCl3) δ 8.46 (d, J=8.5 Hz, 1H), 8.36 (s, 1H), 7.95-7.91 (m, 2H), 7.77 (d, J=1.6 Hz, 1H), 7.70 (s, 1H), 7.54 (t, J=7.9 Hz, 1H), 7.36 (dd, J=7.9, 1.3 Hz, 1H), 4.42 (br s, 2H), 4.14 (s, 3H), 1.46 (s, 9H). LC-MS calcd for C24H25N5O3 (m/e) 431.20, obsd 432 [M+1]+.

Provenance & Evidence