2-Bromo-1,3-thiazole-4-carboxamide → HCID 71008577, compound

Participants

Reaction Steps

This compound was prepared with the same method as described in Example 1 by using 2-bromothiazole-4-carboxylic acid amide (intermediate-2) and acetic acid 2-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzyl ester (intermediate 5). The desired compound was prepared in two steps (10% yield). 1H NMR (300 MHz, DMSO-d6) δ 8.59 (d, J=2.4 Hz, 1H), 8.46 (s, 1H), 7.94 (d, J=1.8 Hz, 1H), 7.88-7.79 (m, 2H), 7.66-7.63 (m, 2H), 4.61-4.52 (m, 2H), 1.46 (s, 9H). LC-MS calcd for C23H21FN4O3S 452.13, obsd 453 [M+1]+.

Provenance & Evidence