HCID 86673710, compound → HCID 71008569, compound

Participants

Reaction Steps

The preparation of 1-(3-(6-tert-butyl-1-oxophthalazin-2(1H)-yl)-2-formylphenyl)-1H-indole-3-carbonitrile, via reaction of 1-(3-bromo-2-formylphenyl)-1H-indole-3-carbonitrile (222 mg, 40% pure, 0.27 mmol, synthesis described above in Example 18, step 1) with 6-tert-butylphthalzin-1(2H)-one (138 mg, 0.68 mmol) was carried out in a procedure analogous to that described in Example 18. Similar work up and purification provided desired product as a light yellow-white solid (82 mg, 66% yield). LC/MS calcd for C28H22N4O2 (m/e) 446.51, obsd 447.0 (M+H, ES+): 1H NMR (300 MHz, CHLOROFORM-d) δ ppm 1.44 (s, 9H) 7.23-7.40 (m, 3H) 7.55 (dd, J=7.93, 1.13 Hz, 2H) 7.72-7.94 (m, 6H) 8.32 (s, 1H) 8.39 (d, J=8.31 Hz, 1H) 9.59 (s, 1H).

Provenance & Evidence