反应详情

温度

80 °C

In a 10 mL round-bottomed flask, 7-(3-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-2-(hydroxymethyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (39 mg, 83.2 μmol, Eq: 1.00) and [hydrogen bis(dimethylphosphinito-kP)]platinum (II) (1 mg, 2.33 μmol, Eq: 0.0280) were combined with Ethanol (2 ml) and Water (1 ml) to give a colorless solution. The reaction mixture was heated to 80° C. and stirred for 2 h. The reaction mixture was diluted with DCM. The reaction mixture was filtered through glass fiber paper. HPLC purification done to obtain 7-[3-(6-tert-Butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid amide (33 mg, 66%, [M+H]+ 487).

1. customto give a colorless solution
2. filtrationThe reaction mixture was filtered through glass fiber paper
3. customHPLC purification