Ethanol → 1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-6-(6-ethoxy-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid amide

HRID 1025629Notes

Reaction equation

HRID 1025629 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]2[C:12](=[C:13]([F:15])[CH:14]=1)[C:11](=[O:16])[N:10]([C:17]1[C:18]([CH2:43][OH:44])=[C:19]([N:23]3[C:27]4=[N:28][C:29]([C:32]5[CH:33]=[N:34][C:35]([O:38][CH2:39][CH3:40])=[CH:36][CH:37]=5)=[CH:30][CH:31]=[C:26]4[C:25]([C:41]#[N:42])=[CH:24]3)[CH:20]=[CH:21][CH:22]=1)[N:9]=[CH:8]2)([CH3:4])([CH3:3])[CH3:2].C([OH:47])C>O>[C:1]([C:5]1[CH:6]=[C:7]2[C:12](=[C:13]([F:15])[CH:14]=1)[C:11](=[O:16])[N:10]([C:17]1[C:18]([CH2:43][OH:44])=[C:19]([N:23]3[C:27]4=[N:28][C:29]([C:32]5[CH:33]=[N:34][C:35]([O:38][CH2:39][CH3:40])=[CH:36][CH:37]=5)=[CH:30][CH:31]=[C:26]4[C:25]([C:41]([NH2:42])=[O:47])=[CH:24]3)[CH:20]=[CH:21][CH:22]=1)[N:9]=[CH:8]2)([CH3:2])([CH3:3])[CH3:4]

Participants

4

Reactant 2

HCID 702EthanolHCID 710085481-(3-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-2-(hydroxymethyl)phenyl)-6-(6-ethoxypyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile

Product 1

HCID 710085161-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-6-(6-ethoxy-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid amideYield 84%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
45 °C

Procedure

In a 25 mL round-bottomed flask, 1-(3-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)-2-(hydroxymethyl)phenyl)-6-(6-ethoxypyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile (36 mg, 61.2 μmol) and [hydrogen bis(dimethylphosphinito-kP)]platinum (II) (263 μg, 0.612 μmol, Eq: 0.01) were combined with ethanol (480 μl) and water (480 μl) to give a colorless solution. The reaction mixture was heated to 45° C. and stirred for 1 h. The crude reaction mixture was concentrated in vacuo. Mixture was diluted with acetonitrile and water and filtered. The resultant filtrate was lyophilized to give 1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-6-(6-ethoxy-pyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid amide (31 mg, 84%, [M+H]+ 607).

Workup

  1. customto give a colorless solution
  2. customThe crude reaction mixture
  3. concentrationwas concentrated in vacuo
  4. additionMixture was diluted with acetonitrile and water
  5. filtrationfiltered

Sources & evidence

ORD record
ord-f3991f14340a4a56bce14baf8efcfc33
Source dataset
uspto-grants-2014_05
Patent number
US08729078B2

Reaction notes

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