Ethanol → HCID 71008051, compound

Participants

Reaction Conditions

Reaction Steps

In a 25 mL round-bottomed flask, 1-(3-(6-tert-butyl-8-fluoro-1-oxophthalazin-2(1H)-yl)phenyl)-1H-pyrazole-4-carbonitrile (87 mg, 225 μmol, Eq: 1.00) and hydrido(dimethylyphosphinous acid-kP) (4.82 mg, 11.2 μmol, Eq: 0.05) were combined with Ethanol (1 ml) and Water (1.00 ml) to give a colorless solution. The reaction mixture was heated to 85° C. and stirred for 45 min. After the required reaction time (conversion checked my LCMS and TLC), the reaction was allowed to come to room temperature and the solvent was removed under vacuum. The mixture was then filtered through the HPLC teflon filter and passed through reverphase HPLC and lyophilized overnight to give 1-[3-(6-tert-butyl-8-fluoro-1-oxo-1H-phthalazin-2-yl)-phenyl]-1H-pyrazole-4-carboxylic acid amide (49 mg, 54%, [M+H]+ 406)

Provenance & Evidence