HCID 58381236, compound → HCID 58381233, compound

Participants

Reaction Steps

Crude 2h (0.102 mmol) was dissolved in a pre-mixed solution of 4N HCl in dioxane (5.00 mL) and deionized water (250 μL) at 10° C. The resultant solution was warmed to room temperature and aged for approximately 1.3 h. After concentrating in vacuo, the residue was purified by flash chromatography on silica gel [100% EtOAc (120 mL) followed by 0%-100% EtOAc/(DCM:MeOH:ammonium hydroxide (95:5:1)] to afford compound Ie-2bx, Ie-2bx: m/z (ES) 497 (MH)+. 1HNMR (500 MHz, CDCl3): δ 8.59 (d, 1H, J=4.3 Hz), 8.05 (d, 2H, J=8.2 Hz), 7.70 (dt, 1H, J=7.6, 1.4 Hz), 7.53 (m, 3H), 7.36 (d, 2H, J=8.7 Hz), 7.21 (dd, 1H, J=6.9, 5.1 Hz), 6.92 (d, 2H, J=8.4 Hz), 5.19 (s, 2H), 4.51 (d, 2H, J=7.1 Hz), 3.75 (s, 1H), 3.10 (bd, 2H, J=12.4 Hz), 2.60 (dt, 2H, J=12.1, 2.0 Hz), 2.21 (m, 1H), 1.86 (bs, 1H), 1.60 (bd, 2H, J=12.3 Hz), 1.28 (m, 2H), 1.04 (s, 9H).

Provenance & Evidence