5-Fluoro-2-methoxyaniline → HCID 67320747, compound

HRID 1025832Notes

Reaction equation

HRID 1025832 reaction equation
[Cl:1][C:2]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][C:6]=1[C:11](N1C2C(=CC=CC=2)CCC1)=[O:12].[F:28][C:29]1[CH:30]=[CH:31][C:32]([O:36][CH3:37])=[C:33]([NH2:35])[CH:34]=1>>[Cl:1][C:2]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:3]=1[O:4][C:5]1[C:6]([C:11]([NH:35][C:33]2[CH:34]=[C:29]([F:28])[CH:30]=[CH:31][C:32]=2[O:36][CH3:37])=[O:12])=[CH:7][N:8]=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 2231055-Fluoro-2-methoxyanilineHCID 53311781[4-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone

Product 1

HCID 67320747HCID 67320747, compound

Procedure

The title compound was prepared in analogy to Example 1, from 4-(2,5-dichloro-phenoxy)-nicotinic acid (Example 1, intermediate) and 5-fluoro-2-methoxy-phenylamine (commercially available; CAS RN 1978-39-8). White solid (74%). MS (ESI): m/z=407.036 [M+H]+.

Sources & evidence

ORD record
ord-dae61c5fc8eb4b00b03631673126c294
Source dataset
uspto-grants-2014_05
Patent number
US08729091B2

Reaction notes

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