HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxy-N-methylaniline → HCID 53311954, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxy-N-methylaniline | HCID 2759579 | — |
| Reactant | [4-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone | HCID 53311781 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | HCID 53311954 | HCID 53311954 | — |
Reaction Steps
The title compound was prepared in analogy to Example 1, from 4-(2,5-dichloro-phenoxy)-nicotinic acid (Example 1, intermediate) and 2-methoxy-N-methylaniline (commercially available; CAS RN 10541-78-3) and using a gradient of n-heptane:ethyl acetate (100:0 to 40:60). The compound was further purified through a second preparative HPLC chromatography (Phenomenex Gemini column) using a gradient of acetonitrile:water (containing 0.05% formic acid) (50:50 to 95:5). White solid (57%). MS (ESI): m/z=403.062 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729091B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-21d7374efd1a4024a4729c7b6c4aa90a |
| Source note | uspto-grants-2014_05 |