HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,5-Difluoro-2-methoxyaniline → HCID 67320675, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,5-Difluoro-2-methoxyaniline | HCID 20111960 | — |
| Reactant | [4-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone | HCID 53311781 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | HCID 67320675 | HCID 67320675 | — |
Reaction Steps
The title compound was prepared in analogy to Example 1, from 4-(2,5-dichloro-phenoxy)-nicotinic acid (Example 1, intermediate) and 4,5-difluoro-2-methoxyaniline (commercially available; CAS RN 1017779-71-3) and using a gradient of n-heptane:ethyl acetate (100:0 to 40:60) for the chromatographic purification. White solid (80%). MS (ESI): m/z=425.027 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729091B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-1ed7be4698094521aaeee4666a23fb8a |
| Source note | uspto-grants-2014_05 |