1177351-07-3 → HCID 67320560, compound

HRID 1025840Notes

Reaction equation

HRID 1025840 reaction equation
[Cl:1][C:2]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][N:8]=[CH:7][C:6]=1[C:11](N1C2C(=CC=CC=2)CCC1)=[O:12].Cl.Cl.[NH2:30][C:31]1[CH:36]=[C:35]([Cl:37])[CH:34]=[CH:33][C:32]=1[N:38]([CH3:40])[CH3:39]>CCCCCCC.C(OCC)(=O)C>[Cl:37][C:35]1[CH:34]=[CH:33][C:32]([N:38]([CH3:40])[CH3:39])=[C:31]([NH:30][C:11](=[O:12])[C:6]2[C:5]([O:4][C:3]3[CH:23]=[C:24]([Cl:27])[CH:25]=[CH:26][C:2]=3[Cl:1])=[CH:10][CH:9]=[N:8][CH:7]=2)[CH:36]=1

Participants

4

Reactant 2

HCID 438105271177351-07-3HCID 53311781[4-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone

Product 1

HCID 67320560HCID 67320560, compound

Reagents, catalysts & solvents 1

HCID 21899848Ethylacetate heptaneSolvent

Procedure

The title compound was prepared in analogy to Example 1, from 4-(2,5-dichloro-phenoxy)-nicotinic acid (Example 1, intermediate), (2-amino-4-chlorphenyl)dimethylamine dihydrochloride (commercially available, CAS RN 183251-88-9), using 5 mole equivalents of base and using a gradient of n-heptane:ethyl acetate (100:0 to 50:50) for the chromatographic purification. White solid (72%). MS (ESI): m/z=436.038 [M+H]+.

Workup

  1. customfor the chromatographic purification

Sources & evidence

ORD record
ord-e701d985e5444d18b24445c284281b4d
Source dataset
uspto-grants-2014_05
Patent number
US08729091B2

Reaction notes

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