Ethylacetate heptane → HCID 53312108, compound

HRID 1025844Notes

Reaction equation

HRID 1025844 reaction equation
[Cl:1][C:2]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:3]=1[O:4][C:5]1[C:10]([C:11]([NH:13][C:14]2[C:15]([N:20]([CH3:22])[CH3:21])=[N:16][CH:17]=[CH:18][CH:19]=2)=[O:12])=[CH:9][N:8]=[CH:7][CH:6]=1.[CH3:28]CCCCCC.C(OCC)(=O)C>>[Cl:1][C:2]1[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:3]=1[O:4][C:5]1[C:10]([C:11]([N:13]([C:14]2[C:15]([N:20]([CH3:22])[CH3:21])=[N:16][CH:17]=[CH:18][CH:19]=2)[CH3:28])=[O:12])=[CH:9][N:8]=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 21899848Ethylacetate heptaneHCID 673201314-(2,5-dichloro-phenoxy)-N-(2-dimethylamino-pyridin-3-yl)-nicotinamide

Product 1

HCID 53312108HCID 53312108, compound

Procedure

The title compound was prepared in analogy to Example 12, from 4-(2,5-dichloro-phenoxy)-N-(2-dimethylamino-pyridin-3-yl)-nicotinamide and using a gradient of n-heptane:ethyl acetate (100:0 to 0:100) for the chromatographic purification. Colorless oil (67%). MS (ESI): m/z=417.088 [M+H]+.

Workup

  1. customfor the chromatographic purification

Sources & evidence

ORD record
ord-321a82cf8a7748dd9ccb379ff3523d10
Source dataset
uspto-grants-2014_05
Patent number
US08729091B2

Reaction notes

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