Ethylacetate heptane → HCID 53312110, compound

HRID 1025847Notes

Reaction equation

[Cl:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([NH:9][C:10](=[O:26])[C:11]2[C:16]([O:17][C:18]3[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:19]=3[Cl:25])=[CH:15][CH:14]=[N:13][CH:12]=2)=[C:4]([N:27]([CH:29]2[CH2:31][CH2:30]2)[CH3:28])[CH:3]=1.[CH3:32]CCCCCC.C(OCC)(=O)C>>[Cl:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([N:9]([CH3:32])[C:10](=[O:26])[C:11]2[C:16]([O:17][C:18]3[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:19]=3[Cl:25])=[CH:15][CH:14]=[N:13][CH:12]=2)=[C:4]([N:27]([CH:29]2[CH2:31][CH2:30]2)[CH3:28])[CH:3]=1

Participants

Reactant 2

HCID 21899848Ethylacetate heptane

HCID 67320677HCID 67320677, compound

Product 1

HCID 53312110HCID 53312110, compound

Procedure

The title compound was prepared in analogy to Example 12, from N-[4-chloro-2-(cyclopropyl-methyl-amino)-5-fluoro-phenyl]-4-(2,5-dichloro-phenoxy)-nicotinamide and using a gradient of n-heptane:ethyl acetate (100:0 to 0:100) for the chromatographic purification. Colorless solid (79%). MS (ESI): m/z=496.058 [M+H]+.

Workup

customfor the chromatographic purification

Sources & evidence

ORD record: ord-d55f20c8a0074721920de60e7dae94e3
Source dataset: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08729091B2

Reaction notes

Loading…