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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1025848Generated: October 30, 2026

[4-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone → HCID 67320677, compound

https://huagongshe.com/reaction/1025848

Reaction equation

Participants

RoleNameHCIDCharge
Reactant[4-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanoneHCID 53311781—
ReactantHCID 67320692HCID 67320692—
SolventEthylacetate heptaneHCID 21899848—
ProductHCID 67320677HCID 67320677—

Reaction Steps

The title compound was prepared in analogy to Example 1, from 4-(2,5-dichloro-phenoxy)-nicotinic acid (Example 1, intermediate) and 4-chloro-N2-cyclopropyl-5-fluoro-N2-methyl-benzene-1,2-diamine and using a gradient of n-heptane:ethyl acetate (100:0 to 30:70) for the chromatographic purification. Colorless solid (70%). MS (ESI): m/z=446.083 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08729091B2
Source datasetuspto-grants-2014_05
ORD IDord-79a981fb803745e5a478302f001f4df9
Source noteuspto-grants-2014_05