Water → HCID 53311107, compound

Participants

Reaction Steps

To a solution of 0.040 g (0.065 mmol) 4-{2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-benzoic acid methyl ester (Example 43) in 0.5 mL dioxane were added 0.5 mL water and 0.003 g (0.071 mmol) lithiumhydroxide monohydrate. The resulting suspension was stirred at room temperature for 2 h, followed by heating to 80° C. for 1 hour. The organic solvent was removed by evaporation and the pH of the resulting solution was adjusted to 1 to 2 using 1M aqueous hydrochloric acid. The suspension was stirred for 2 hours at room temperature, filtered and washed with water to yield the desired compound as a light brown solid (0.020 g, 51%). MS (ESI): m/z=603.12 [M+H]+.

Provenance & Evidence