HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-amino-4-methylthiazole-5-carboxylate → HCID 53311108, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-amino-4-methylthiazole-5-carboxylate | HCID 343747 | — |
| Reactant | {2,5-Dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoylamino}-acetic acid methyl ester | HCID 53312194 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | HCID 53311108 | HCID 53311108 | — |
Reaction Steps
The title compound was prepared in analogy to Example 1, from 2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoic acid (Example 29, intermediate) and 2-amino-4-methyl-thiazole-5-carboxylic acid ethyl ester (commercially available, CAS RN 7210-76-6) and using a gradient of n-heptane:ethyl acetate (100:0 to 0:100) for the chromatographic purification. Yellow solid (0.182 g; 67%). MS (ESI): m/z=652.12 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729091B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-c3f9b230bcce46bea072277d6ad2488c |
| Source note | uspto-grants-2014_05 |