Diethanolamine → HCID 53311185, compound

Participants

Reaction Steps

The title compound was prepared in analogy to Example 1, from 2,5-dichloro-4-[3-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-pyridin-4-yloxy]-benzoic acid (Example 29, intermediate) and 2-(2-hydroxy-ethylamino)-ethanol (commercially available, CAS RN 111-42-2). The product was purified on a preparative HPLC system (Phenomenex Gemini column) using a gradient of acetonitrile:water (containing 0.05% formic acid) (10:90 to 98:2) to give the desired compound as a light brown solid (71%). MS (ESI): m/z=571.150 [M+H]+.

Provenance & Evidence