HRID1025898

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1cc(Oc2cc(Cl)c(C(=O)O)cc2Cl)c(C(=O)N2CCN(C3CC3)c3ccccc32)cn1

HCID53311449

未命名化合物

HCID178510704

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(Oc2cc(Cl)c(C(=O)NCc3nnn[nH]3)cc2Cl)c(C(=O)N2CCN(C3CC3)c3ccccc32)cn1

HCID178428832

未命名化合物

收率 40%

PROCEDURE

实验过程

The title compound was prepared in analogy to Example 38, from 2,5-dichloro-4-[5-(4-cyclopropyl-3,4-dihydro-2H-quinoxaline-1-carbonyl)-2-methyl-pyridin-4-yloxy]-benzoic acid (Example 66) and 5-(aminomethyl)-tetrazole (commercially available, CAS RN 31602-63-8) to provide 47 mg (40%) of the title compound as a light yellow solid. MS (ESI): m/z=579.142 [M+H]+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d86d868ae4384a779a96e76050485cbc
来源数据集: uspto-grants-2014_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08729091B2
来源说明: uspto-grants-2014_05

反应 SMILES

[Cl:1][C:2]1[CH:10]=[C:9]([O:11][C:12]2[C:17]([C:18]([N:20]3[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[N:23]([CH:30]4[CH2:32][CH2:31]4)[CH2:22][CH2:21]3)=[O:19])=[CH:16][N:15]=[C:14]([CH3:33])[CH:13]=2)[C:8]([Cl:34])=[CH:7][C:3]=1[C:4](O)=[O:5].[NH2:35][CH2:36][C:37]1[NH:41][N:40]=[N:39][N:38]=1>>[Cl:1][C:2]1[CH:10]=[C:9]([O:11][C:12]2[C:17]([C:18]([N:20]3[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[N:23]([CH:30]4[CH2:31][CH2:32]4)[CH2:22][CH2:21]3)=[O:19])=[CH:16][N:15]=[C:14]([CH3:33])[CH:13]=2)[C:8]([Cl:34])=[CH:7][C:3]=1[C:4]([NH:35][CH2:36][C:37]1[NH:41][N:40]=[N:39][N:38]=1)=[O:5]