1,2,3,4-Tetrahydroquinoxaline → [4-(2,5-Dichloro-phenoxy)-pyrimidin-5-yl]-(3,4-dihydro-2H-quinoxalin-1-yl)-methanone

HRID 1025906ノート

反応式

HRID 1025906 の反応式
[Cl:1][C:2]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:3]=1[O:4][C:5]1[C:10]([C:11]([OH:13])=O)=[CH:9][N:8]=[CH:7][N:6]=1.[NH:19]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[NH:22][CH2:21][CH2:20]1>>[Cl:1][C:2]1[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][C:3]=1[O:4][C:5]1[C:10]([C:11]([N:19]2[C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[NH:22][CH2:21][CH2:20]2)=[O:13])=[CH:9][N:8]=[CH:7][N:6]=1

参加物

3

反応物 2

HCID 770281,2,3,4-TetrahydroquinoxalineHCID 673202614-(2,5-Dichloro-phenoxy)-pyrimidine-5-carboxylic acid

生成物 1

HCID 53311620[4-(2,5-Dichloro-phenoxy)-pyrimidin-5-yl]-(3,4-dihydro-2H-quinoxalin-1-yl)-methanone収率 20%

実験手順

The title compound was prepared in analogy to Example 77, from 4-(2,5-dichloro-phenoxy)-pyrimidine-5-carboxylic acid (Example 76, intermediate a) and 1,2,3,4-tetrahydroquinoxaline (commercially available, CAS RN 3476-89-9). The compound was purified by preparative HPLC (Phenomenex Gemini column) using a gradient of acetonitrile:water (10:90 to 98:2) to give 16 mg (20%) of the desired compound. MS (ESI): m/z=401.0 [M+H]+.

後処理

  1. customThe compound was purified by preparative HPLC (Phenomenex Gemini column)

出典と根拠

ORDレコード
ord-5e81c4dbb5ec4fd28dde655943668258
出典データセット
uspto-grants-2014_05
特許番号
US08729091B2

反応ノート

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