Bromine → HCID 90142044, compound

Participants

Reaction Steps

A solution of 4-(chloromethyl)-4-methyloxazolidin-2-one (2.70 g, 18.1 mmol) in 1.0 M NaOH (20 ml) was cooled to 0° C. Bromine (1.0 ml, 20 mmol) was added dropwise, and stirred for 30 min. The precipitate was filtered off to give the title compound (2.32 g, 10.2 mmol, 56%). 1H NMR (CDCl3, 400 MHz) δ 1.44 (s, 3H), 3.49 (d, J=12.0 Hz, 1H), 3.65 (d, J=12.0 Hz, 1H), 4.22 (d, J=8.8 Hz, 1H), 4.57 (d, J=8.4 Hz, 1H). LRMS (ESI/APCI): 228 [M+H]+.

Provenance & Evidence