4,4-Bis(chloromethyl)-1,3-oxazolidin-2-one → HCID 53359811, compound

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Reaction Steps

To a solution of 4,4-bis(chloromethyl)oxazolidin-2-one (1.11 g, 6.03 mmol) in MeOH (10 ml) was added tert-butylhypochlorite (1.0 ml, 8.4 mmol). The solution was stirred for 1 h, concentrated in vacuo, and the residue purified by flash chromatography (30% to 80% EtOAc in hexanes) to afford the title compound as a white solid (1.04 g, 4.76 mmol, 79%). 1H NMR (CDCl3, 400 MHz) δ 3.78 (d, J=12.0 Hz, 2H), 3.84 (d, J=12.4 Hz, 2H), 4.55 (s, 2H). LRMS (ESI/APCI): 228 [M+H]+.

Provenance & Evidence