3-Chloro-4-methylphenylboronic acid → (6-Chloro-4-(3-chloro-4-methylphenyl)-5-(2,2,2-trifluoroethoxy)pyridin-2-yl)methanol

Participants

Role	Name	HCID	Charge
Reactant	3-Chloro-4-methylphenylboronic acid	HCID 3854610	—
Reactant	[6-Chloro-4-iodo-5-(2,2,2-trifluoro-ethoxy)-pyridin-2-yl]-methanol	HCID 86663131	—
Product	(6-Chloro-4-(3-chloro-4-methylphenyl)-5-(2,2,2-trifluoroethoxy)pyridin-2-yl)methanol	HCID 86663142	—

Reaction Steps

The title compound was synthesized in analogy to Example B using [4-iodo-6-chloro-5-(2,2,2-trifluoro-ethoxy)-pyridin-2-yl]-methanol (example A) and B-(3-chloro-4-methylphenyl)-boronic acid, (CAN 175883-63-3) as starting materials; LC-MS (UV peak area/ESI) 100%, 366.0269 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08729105B2
Source dataset	uspto-grants-2014_05
ORD ID	ord-b6ebb8c009e5470b8e9f115a332c1c57
Source note	uspto-grants-2014_05