3,4-Difluorobenzeneboronic acid → 6-(Cyclopropylmethoxy)-5-(3,4-difluorophenyl)nicotinic acid

HRID 1025993Notes

Reaction equation

HRID 1025993 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:13]([OH:15])=[O:14])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][CH:10]1[CH2:12][CH2:11]1.[F:16][C:17]1[CH:18]=[C:19](B(O)O)[CH:20]=[CH:21][C:22]=1[F:23]>>[CH:10]1([CH2:9][O:8][C:7]2[C:2]([C:20]3[CH:19]=[CH:18][C:17]([F:16])=[C:22]([F:23])[CH:21]=3)=[CH:3][C:4]([C:13]([OH:15])=[O:14])=[CH:5][N:6]=2)[CH2:12][CH2:11]1

Participants

3

Reactant 2

HCID 27343373,4-Difluorobenzeneboronic acidHCID 211097085-Bromo-6-(cyclopropylmethoxy)nicotinic acid

Product 1

HCID 666786196-(Cyclopropylmethoxy)-5-(3,4-difluorophenyl)nicotinic acid

Procedure

The title compound was synthesized in analogy to Example BQ using 5-bromo-6-(cyclopropylmethoxy)-3-pyridinecarboxylic acid (CAN 912454-38-7) and B-(3,4-difluorophenyl)-boronic acid, (CAN 168267-41-2) as starting materials; MS (ESI): 304.2 (M−H)−.

Sources & evidence

ORD record
ord-7ff4d0cba5b141aebd0d88026b53f08c
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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