3,4-Difluorobenzeneboronic acid → HCID 66678797, compound

HRID 1025994Notes

Reaction equation

HRID 1025994 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:13]([OH:15])=[O:14])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][CH2:10][O:11][CH3:12].[F:16][C:17]1[CH:18]=[C:19](B(O)O)[CH:20]=[CH:21][C:22]=1[F:23]>>[F:16][C:17]1[CH:18]=[C:19]([C:2]2[C:7]([O:8][CH2:9][CH2:10][O:11][CH3:12])=[N:6][CH:5]=[C:4]([CH:3]=2)[C:13]([OH:15])=[O:14])[CH:20]=[CH:21][C:22]=1[F:23]

Participants

3

Reactant 2

HCID 27343373,4-Difluorobenzeneboronic acidHCID 211097055-Bromo-6-(2-methoxy-ethoxy)-nicotinic acid

Product 1

HCID 66678797HCID 66678797, compound

Procedure

The title compound was synthesized in analogy to Example BQ using 5-bromo-6-(2-methoxyethoxy)-3-pyridinecarboxylic acid (CAN 912454-34-3) and B-(3,4-difluorophenyl)-boronic acid, (CAN 168267-41-2) as starting materials; MS (ESI): 308.3 (M−H)−.

Sources & evidence

ORD record
ord-1acae6506b9541bab3d8191eeb25e498
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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