Benzo[C][1,2,5]Oxadiazole-5-Boronic Acid → HCID 66678872, compound

HRID 1025997Notes

Reaction equation

HRID 1025997 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:14]([OH:16])=[O:15])[CH:5]=[N:6][C:7]=1[O:8][CH2:9][C:10]([F:13])([F:12])[F:11].[N:17]1[O:18][N:19]=[C:20]2[CH:25]=[C:24](B(O)O)[CH:23]=[CH:22][C:21]=12>>[N:17]1[O:18][N:19]=[C:20]2[CH:25]=[C:24]([C:2]3[C:7]([O:8][CH2:9][C:10]([F:13])([F:12])[F:11])=[N:6][CH:5]=[C:4]([CH:3]=3)[C:14]([OH:16])=[O:15])[CH:23]=[CH:22][C:21]=12

Participants

3

Reactant 2

HCID 4672597Benzo[C][1,2,5]Oxadiazole-5-Boronic AcidHCID 581925925-Bromo-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

Product 1

HCID 66678872HCID 66678872, compound

Procedure

The title compound was synthesized in analogy to Example BQ using 5-bromo-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid (CAN 1211586-75-2) and B-2,1,3-benzoxadiazol-5-yl-boronic acid, (CAN 426268-09-9) as starting materials; LC-MS (UV peak area/ESI) 48%, 338.0 (M−H)−.

Sources & evidence

ORD record
ord-f088ed0cadaf47f2a401c5345c19957c
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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