(3-Methoxyisoxazol-5-yl)methanamine hydrochloride → 5-(4-chloro-phenyl)-N-(3-methoxy-isoxazol-5-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

HRID 1026005Notes

Reaction equation

HRID 1026005 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:20](O)=[O:21])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.Cl.[CH3:24][O:25][C:26]1[CH:30]=[C:29]([CH2:31][NH2:32])[O:28][N:27]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:19])([F:17])[F:18])=[N:12][CH:11]=[C:10]([CH:9]=2)[C:20]([NH:32][CH2:31][C:29]2[O:28][N:27]=[C:26]([O:25][CH3:24])[CH:30]=2)=[O:21])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 21292276(3-Methoxyisoxazol-5-yl)methanamine hydrochlorideHCID 666869715-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid

Product 1

HCID 569297555-(4-chloro-phenyl)-N-(3-methoxy-isoxazol-5-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid (CAS Registry No. 1018782-82-5) and 3-methoxy-5-isoxazolemethanamine hydrochloride as starting materials, LC-MS (UV peak area/ESI) 100%, 442.079 (M+H)+.

Sources & evidence

ORD record
ord-2bb54a5452c644059b74132c1190e832
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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