(2-Propylthiazol-4-yl)methanamine → 5-(4-chloro-phenyl)-N-(2-propyl-thiazol-4-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

HRID 1026009Notes

Reaction equation

HRID 1026009 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:20](O)=[O:21])[CH:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[CH2:23]([C:26]1[S:27][CH:28]=[C:29]([CH2:31][NH2:32])[N:30]=1)[CH2:24][CH3:25]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:18])([F:17])[F:19])=[N:12][CH:11]=[C:10]([CH:9]=2)[C:20]([NH:32][CH2:31][C:29]2[N:30]=[C:26]([CH2:23][CH2:24][CH3:25])[S:27][CH:28]=2)=[O:21])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 28064788(2-Propylthiazol-4-yl)methanamineHCID 666869715-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid

Product 1

HCID 666784925-(4-chloro-phenyl)-N-(2-propyl-thiazol-4-ylmethyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-(4-chlorophenyl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid (CAS Registry No. 1018782-82-5) and 2-propyl-4-thiazolemethanamine as starting materials, LC-MS (UV peak area/ESI) 99%, 470.090 (M+H)+.

Sources & evidence

ORD record
ord-642827bd2eaa40f59766f6ee6bc1390b
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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