C-(5-Trifluoromethyl-[1,2,4]oxadiazol-3-yl)-methylamine hydrochloride → 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-N-(5-trifluoromethyl-[1,2,4]oxadiazol-3-ylmethyl)-nicotinamide

Participants

Role	Name	HCID	Charge
Reactant	C-(5-Trifluoromethyl-[1,2,4]oxadiazol-3-yl)-methylamine hydrochloride	HCID 66686733	—
Reactant	5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid	HCID 66686971	—
Product	5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-N-(5-trifluoromethyl-[1,2,4]oxadiazol-3-ylmethyl)-nicotinamide	HCID 56928271	—

Reaction Steps

The title compound was synthesized in analogy to Example 1, using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (CAS Registry No. 1018782-82-5) and C-(5-trifluoromethyl-[1,2,4]oxadiazol-3-yl)-methylamine hydrochloride (example AI), LC-MS (UV peak area/ESI) 93%, 479.035 (M−H)−.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08729105B2
Source dataset	uspto-grants-2014_05
ORD ID	ord-181cf2a90aea4e2488d5470d40fceaf3
Source note	uspto-grants-2014_05