HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)methanamine → 4-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyrimidine-2-carboxylic acid (5-cyclopropyl-[1,2,4]oxadiazol-3-ylmethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)methanamine | HCID 28064907 | — |
| Reactant | 4-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyrimidine-2-carboxylic acid | HCID 66678819 | — |
| Product | 4-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyrimidine-2-carboxylic acid (5-cyclopropyl-[1,2,4]oxadiazol-3-ylmethyl)-amide | HCID 56928272 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using 4-(4-chloro-phenyl)-5-cyclopropylmethoxy-pyrimidine-2-carboxylic acid (example T) and [(5-cyclopropyl-1,2,4-oxadiazol-3-yl)methyl]amine (CAS Registry No. 1082420-52-7), LC-MS (UV peak area/ESI) 100%, 426.132 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729105B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-b29fa9291c914c48afa2ce6b300f8dc8 |
| Source note | uspto-grants-2014_05 |