4-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid → 4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)picolinamide

Participants

Role	Name	HCID	Charge
Reactant	4-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid	HCID 66678685	—
Reactant	[3-(Trifluoromethyl)-1,2,4-oxadiazol-5-yl]methanamine hydrochloride	HCID 66687518	—
Product	4-(4-chlorophenyl)-5-(cyclopropylmethoxy)-N-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)picolinamide	HCID 56928377	—

Reaction Steps

The title compound was synthesized in analogy to Example 1, using 4-(4-chloro-phenyl)-5-(cyclopropylmethyloxy)-pyridine-2-carboxylic acid (example H) and C-(3-trifluoromethyl-[1,2,4]oxadiazol-5-yl)-methylamine hydrochloride (CAS registry No. 944905-93-5; example AK) as starting materials; LC-MS (UV peak area/ESI) 100%, 453.0924 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08729105B2
Source dataset	uspto-grants-2014_05
ORD ID	ord-b0f87b691a9949f5830a392e2f1336d2
Source note	uspto-grants-2014_05