HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Methoxyisoxazol-5-yl)methanamine hydrochloride → 4-(3,4-dichlorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-5-(2,2,2-trifluoroethoxy)pyrimidine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Methoxyisoxazol-5-yl)methanamine hydrochloride | HCID 21292276 | — |
| Reactant | 4-(3,4-Dichloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyrimidine-2-carboxylic acid | HCID 66678780 | — |
| Product | 4-(3,4-dichlorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-5-(2,2,2-trifluoroethoxy)pyrimidine-2-carboxamide | HCID 56928480 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using 4-(3,4-dichloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyrimidine-2-carboxylic acid (example AA) and 3-methoxy-5-isoxazolemethanamine hydrochloride as starting materials, 477.0 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729105B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-7081044798744abd8459185e78414564 |
| Source note | uspto-grants-2014_05 |