1060817-49-3 → HCID 56928483, compound

HRID 1026028Notes

Reaction equation

HRID 1026028 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:12][N:11]=[C:10]([C:20](O)=[O:21])[CH:9]=2)=[CH:4][CH:3]=1.[CH:23]1([C:26]2[O:30][N:29]=[C:28]([CH2:31][NH2:32])[CH:27]=2)[CH2:25][CH2:24]1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:17])([F:19])[F:18])=[CH:12][N:11]=[C:10]([C:20]([NH:32][CH2:31][C:28]3[CH:27]=[C:26]([CH:23]4[CH2:25][CH2:24]4)[O:30][N:29]=3)=[O:21])[CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 280650741060817-49-3HCID 66687043HCID 66687043, compound

Product 1

HCID 56928483HCID 56928483, compound

Procedure

The title compound was synthesized in analogy to Example 1, using 4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (example D) and 5-cyclopropyl-3-isoxazolemethanamine (CAS Registry No. 1060817-49-3) as starting materials; LC-MS (UV peak area/ESI) 98.6%, 452.0979 (M+H)+.

Sources & evidence

ORD record
ord-fdd3918f4b7a45edbc116da20cdc29fe
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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