5-(1-Methylethyl)-3-isoxazolemethanamine → 5-(4-chlorophenyl)-N-((5-isopropylisoxazol-3-yl)methyl)-6-(2,2,2-trifluoroethoxy)nicotinamide

HRID 1026030Notes

Reaction equation

HRID 1026030 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([O:17][CH2:18][C:19]([F:22])([F:21])[F:20])=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[CH3:23][CH:24]([C:26]1[O:30][N:29]=[C:28]([CH2:31][NH2:32])[CH:27]=1)[CH3:25]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9]([O:17][CH2:18][C:19]([F:20])([F:22])[F:21])=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([NH:32][CH2:31][C:28]2[CH:27]=[C:26]([CH:24]([CH3:25])[CH3:23])[O:30][N:29]=2)=[O:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 280651515-(1-Methylethyl)-3-isoxazolemethanamineHCID 666869715-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid

Product 1

HCID 666788805-(4-chlorophenyl)-N-((5-isopropylisoxazol-3-yl)methyl)-6-(2,2,2-trifluoroethoxy)nicotinamide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (CAS Registry No. 1018782-82-5) and 5-(1-methylethyl)-3-isoxazolemethanamine (CAS Registry No. 154016-49-6) as starting materials, 454.1 (M+H)+.

Sources & evidence

ORD record
ord-ef8304b9f3d24d62bc8ad39b017397b5
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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