(3-Cyclopropyl-1,2-oxazol-5-yl)methanamine → 4-(4-chlorophenyl)-N-((3-cyclopropylisoxazol-5-yl)methyl)-5-(2,2,2-trifluoroethoxy)picolinamide

HRID 1026032Notes

Reaction equation

HRID 1026032 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:12][N:11]=[C:10]([C:20]([OH:22])=O)[CH:9]=2)=[CH:4][CH:3]=1.[CH:23]1([C:26]2[CH:30]=[C:29]([CH2:31][NH2:32])[O:28][N:27]=2)[CH2:25][CH2:24]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:13]([O:14][CH2:15][C:16]([F:18])([F:19])[F:17])=[CH:12][N:11]=[C:10]([C:20]([NH:32][CH2:31][C:29]3[O:28][N:27]=[C:26]([CH:23]4[CH2:25][CH2:24]4)[CH:30]=3)=[O:22])[CH:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 64156762(3-Cyclopropyl-1,2-oxazol-5-yl)methanamineHCID 66687043HCID 66687043, compound

Product 1

HCID 569285934-(4-chlorophenyl)-N-((3-cyclopropylisoxazol-5-yl)methyl)-5-(2,2,2-trifluoroethoxy)picolinamide

Procedure

The title compound was synthesized in analogy to Example 1, using 4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (example D) and 3-cyclopropyl-5-isoxazolemethanamine (CAS Registry No. 851434-73-6) as starting materials; LC-MS (UV peak area/ESI) 97.6%, 452.0973 (M+H)+.

Sources & evidence

ORD record
ord-f6e698171fd243f980b478925bfb8f50
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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