HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3-Methoxyisoxazol-5-yl)methanamine hydrochloride → (S)-5-(4-chlorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-6-(1,1,1-trifluoropropan-2-yloxy)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3-Methoxyisoxazol-5-yl)methanamine hydrochloride | HCID 21292276 | — |
| Reactant | (S)-5-(4-Chlorophenyl)-6-(1,1,1-trifluoropropan-2-yloxy)nicotinic acid | HCID 66678484 | — |
| Product | (S)-5-(4-chlorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-6-(1,1,1-trifluoropropan-2-yloxy)nicotinamide | HCID 56928594 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using (S)-5-(4-chlorophenyl)-6-(1,1,1-trifluoropropan-2-yloxy)nicotinic acid (Example AO) and 3-methoxy-5-isoxazolemethanamine hydrochloride as starting materials. MS: 456.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729105B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-ba936538b3f749a083030412adb71c24 |
| Source note | uspto-grants-2014_05 |