(3-Methoxyisoxazol-5-yl)methanamine hydrochloride → (S)-4-(4-chlorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-5-(1,1,1-trifluoropropan-2-yloxy)picolinamide

HRID 1026036Notes

Reaction equation

HRID 1026036 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([O:14][C@@H:15]([CH3:20])[C:16]([F:19])([F:18])[F:17])=[CH:12][N:11]=[C:10]([C:21](O)=[O:22])[CH:9]=2)=[CH:4][CH:3]=1.Cl.[CH3:25][O:26][C:27]1[CH:31]=[C:30]([CH2:32][NH2:33])[O:29][N:28]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:13]([O:14][C@@H:15]([CH3:20])[C:16]([F:19])([F:17])[F:18])=[CH:12][N:11]=[C:10]([C:21]([NH:33][CH2:32][C:30]3[O:29][N:28]=[C:27]([O:26][CH3:25])[CH:31]=3)=[O:22])[CH:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 21292276(3-Methoxyisoxazol-5-yl)methanamine hydrochlorideHCID 66678598(S)-4-(4-chlorophenyl)-5-(1,1,1-trifluoropropan-2-yloxy)picolinic acid

Product 1

HCID 56928597(S)-4-(4-chlorophenyl)-N-((3-methoxyisoxazol-5-yl)methyl)-5-(1,1,1-trifluoropropan-2-yloxy)picolinamide

Procedure

The title compound was synthesized in analogy to Example 1, using (S)-4-(4-chlorophenyl)-5-(1,1,1-trifluoropropan-2-yloxy)picolinic acid (example AR) and 3-methoxy-5-isoxazolemethanamine hydrochloride as starting materials. MS: 456.1 (M+H)+.

Sources & evidence

ORD record
ord-9047ed42e8cc4d168767eadaa767659a
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

Loading…