HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(1-Methylethyl)-1,2,4-oxadiazole-5-methanamine → 4-(4-chlorophenyl)-N-((3-isopropyl-1,2,4-oxadiazol-5-yl)methyl)-5-(2,2,2-trifluoroethoxy)picolinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(1-Methylethyl)-1,2,4-oxadiazole-5-methanamine | HCID 28063156 | — |
| Reactant | HCID 66687043 | HCID 66687043 | — |
| Product | 4-(4-chlorophenyl)-N-((3-isopropyl-1,2,4-oxadiazol-5-yl)methyl)-5-(2,2,2-trifluoroethoxy)picolinamide | HCID 56928692 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 1, using 4-(4-chloro-phenyl)-5-(2,2,2-trifluoro-ethoxy)-pyridine-2-carboxylic acid (example D) and 3-(1-methylethyl)-1,2,4-oxadiazole-5-methanamine (CAN 936940-67-9) as starting materials, LC-MS (UV peak area/ESI) 97.2%, 455.1099 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729105B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-7487dcadba1d4000aeb093662449b79e |
| Source note | uspto-grants-2014_05 |