(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)methanamine → 5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (3-cyclopropyl-[1,2,4]oxadiazol-5-ylmethyl)-amide

HRID 1026046Notes

Reaction equation

HRID 1026046 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:20](O)=[O:21])[N:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[CH:23]1([C:26]2[N:30]=[C:29]([CH2:31][NH2:32])[O:28][N:27]=2)[CH2:25][CH2:24]1>>[CH:23]1([C:26]2[N:30]=[C:29]([CH2:31][NH:32][C:20]([C:10]3[N:11]=[N:12][C:13]([O:14][CH2:15][C:16]([F:17])([F:18])[F:19])=[C:8]([C:5]4[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=4)[CH:9]=3)=[O:21])[O:28][N:27]=2)[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 20729516(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)methanamineHCID 66678582HCID 66678582, compound

Product 1

HCID 569287995-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (3-cyclopropyl-[1,2,4]oxadiazol-5-ylmethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 41, using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (example M) and 3-cyclopropyl-1,2,4-oxadiazole-5-methanamine (CAS Registry No. 428507-31-7) as starting materials; LC-MS (UV peak area/ESI) 97.6%, 454.2 (M+H)+.

Sources & evidence

ORD record
ord-946ac5d5770841a499d8a9b5b53a27b4
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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