(3-Cyclopropyl-1,2-oxazol-5-yl)methanamine → 5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (3-cyclopropyl-isoxazol-5-ylmethyl)-amide

HRID 1026047Notes

Reaction equation

HRID 1026047 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([C:20](O)=[O:21])[N:11]=[N:12][C:13]=2[O:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[CH:23]1([C:26]2[CH:30]=[C:29]([CH2:31][NH2:32])[O:28][N:27]=2)[CH2:25][CH2:24]1>>[CH:23]1([C:26]2[CH:30]=[C:29]([CH2:31][NH:32][C:20]([C:10]3[N:11]=[N:12][C:13]([O:14][CH2:15][C:16]([F:19])([F:17])[F:18])=[C:8]([C:5]4[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=4)[CH:9]=3)=[O:21])[O:28][N:27]=2)[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 64156762(3-Cyclopropyl-1,2-oxazol-5-yl)methanamineHCID 66678582HCID 66678582, compound

Product 1

HCID 666788875-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (3-cyclopropyl-isoxazol-5-ylmethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 41, using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (example M) and 3-cyclopropyl-5-isoxazolemethanamine (CAN 851434-73-6) as starting materials, LC-MS (UV peak area/ESI) 92.9%, 453.2 (M+H)+.

Sources & evidence

ORD record
ord-ea698fe9653446dcbc7d8148d2625078
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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