HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid → 6-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid (5-trifluoromethyl-isoxazol-3-ylmethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid | HCID 66678605 | — |
| Reactant | (5-(Trifluoromethyl)-1,2-oxazol-3-yl)methanamine hydrochloride | HCID 66687333 | — |
| Product | 6-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid (5-trifluoromethyl-isoxazol-3-ylmethyl)-amide | HCID 56929001 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 41 using 6-(4-Chloro-phenyl)-5-cyclopropylmethoxy-pyridine-2-carboxylic acid (example AW) and 5-trifluoromethyl-isoxazol-3-methanamine hydrochloride (example BF) as starting materials, LC-MS (UV peak area/ESI) 97.8%, 452.4 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08729105B2 |
| Source dataset | uspto-grants-2014_05 |
| ORD ID | ord-f0434b0dc5ac404992f2ac1bccc98aff |
| Source note | uspto-grants-2014_05 |