[3-(Trifluoromethyl)-1,2-oxazol-5-yl]methanamine → 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-N-(3-trifluoromethyl-isoxazol-5-ylmethyl)-nicotinamide

HRID 1026053Notes

Reaction equation

HRID 1026053 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([O:17][CH2:18][C:19]([F:22])([F:21])[F:20])=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([OH:15])=O)=[CH:4][CH:3]=1.[F:23][C:24]([F:33])([F:32])[C:25]1[CH:29]=[C:28]([CH2:30][NH2:31])[O:27][N:26]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9]([O:17][CH2:18][C:19]([F:21])([F:22])[F:20])=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([NH:31][CH2:30][C:28]2[O:27][N:26]=[C:25]([C:24]([F:33])([F:32])[F:23])[CH:29]=2)=[O:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 54405670[3-(Trifluoromethyl)-1,2-oxazol-5-yl]methanamineHCID 666869715-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid

Product 1

HCID 569290025-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-N-(3-trifluoromethyl-isoxazol-5-ylmethyl)-nicotinamide

Procedure

The title compound was synthesized in analogy to Example 1 using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (CAS Registry No. 1018782-82-5) and 3-trifluoromethyl-isoxazol-5-methanamine (example BA) as starting materials; MS: 478.0 (M+H)+.

Sources & evidence

ORD record
ord-afc687f3cad040a19d78e8a9003dc8d0
Source dataset
uspto-grants-2014_05
Patent number
US08729105B2

Reaction notes

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