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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1026054Generated: November 3, 2026

[3-(Trifluoromethyl)-1,2-oxazol-5-yl]methanamine → 5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (3-trifluoromethyl-isoxazol-5-ylmethyl)-amide

https://huagongshe.com/reaction/1026054

Reaction equation

Participants

RoleNameHCIDCharge
Reactant[3-(Trifluoromethyl)-1,2-oxazol-5-yl]methanamineHCID 54405670—
ReactantHCID 66678582HCID 66678582—
Product5-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (3-trifluoromethyl-isoxazol-5-ylmethyl)-amideHCID 56929003—

Reaction Steps

The title compound was synthesized in analogy to Example 1, using 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid (example M) and 3-trifluoromethyl-isoxazol-5-methanamine (example BA) as starting materials; MS: 480.0 (M)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08729105B2
Source datasetuspto-grants-2014_05
ORD IDord-f3f3625e5875492cadf33fbfd966d278
Source noteuspto-grants-2014_05